People with disabilities don’t have enough dental care facilities. IU is constructing a new clinic

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02

Ossium Health® and Be The Match® Unveil Partnership to Increase Bone Marrow Transplant Accessibility and Treatment Efficiency

Ossium Health, a bioengineering company developing the world’s first bank of organ donor bone marrow, and the National Marrow Donor Program® (NMDP)/Be The Match®, a global leader working to save lives through cellular therapy, today announced their partnership to expand access to vital bone marrow and accelerate the industry’s ability to make bone marrow transplants accessible at scale.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230831050319/en/

Ossium and NMDP/Be The Match are kicking off a clinical trial to demonstrate the safety and efficacy of Ossium’s bone marrow product. PRESERVE I “A First-in-Human Study of HLA-Partially to Fully Matched Allogeneic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients with Hematologic Malignancies” (NCT05589896) is anticipated to open in Q4 2023. Once the trial is completed, a subsequent multi-center, phase II clinical trial will open. With favorable trial results, the two organizations will then work to integrate the bone marrow donations in Ossium Health’s proprietary bank into NMDP/Be The Match’s national donor registry. Once on the national registry, Ossium Health’s donated bone marrow will become a resource for doctors from nearly 160 U.S. transplant centers who utilize the Be The Match Registry® to offer patients additional options when searching for matches. This partnership will dramatically increase Ossium’s ability to serve patients at scale, and allow NMDP/Be The Match to offer a new source of life-saving bone marrow to a wider group of patients in need.

“With 18,000 patients in need of a bone marrow transplant each year, we need to ensure that people have access to the broadest set of donors possible to make life-saving matches a reality for all,” said Kevin Caldwell, CEO & Co-Founder at Ossium Health. “We’re thrilled to work with NMDP/Be The Match to supplement their registry with viable donors that enable more people to receive on-demand treatment.”

Ossium isolates bone marrow from authorized deceased donors, which is phenotypically and functionally equivalent to cells from living donors, and then cryopreserves and stores the marrow until it is requested by a physician. Ossium’s approach can drastically reduce the wait period for bone marrow transplants. Once the clinical trials and registry integration are complete, Ossium will provide off-the-shelf bone marrow solutions, complementing NMDP/Be The Match’s existing U.S. registry of more than 9 million potential living donors.

“At Be The Match, we’re devoted to maximizing the opportunity for patients to find the best possible match, so Ossium is a great partner for us,” said Amy Ronneberg, CEO of NMDP/Be The Match. “We’re energized by their industry-shifting donation source that could open the door for so many more people to receive the bone marrow transplants they need, and look forward to all that we can accomplish together to improve the lives of people battling blood cancer and blood disorders.”

To learn more about Ossium’s efforts to fight blood cancer, see this AP article.

About Ossium Health®

Ossium Health is a bioengineering company that leverages its unique deceased donor bone marrow banking platform to develop stem cell therapies for patients with life-threatening blood and immune diseases. Founded in 2016, the company is led by Kevin Caldwell, its CEO, Co-Founder & President, and Erik Woods, its Chief Science Officer, Co-Founder & EVP. Ossium Health is an FDA-Registered Tissue Bank, is accredited by the Commission on Office Laboratory Accreditation (COLA), and its laboratory is certified under the Clinical Laboratory Improvement Amendment (CLIA).

About the National Marrow Donor Program® (NMDP)/Be The Match®

The National Marrow Donor Program® (NMDP)/Be The Match® is the leading global partner working to save lives through cellular therapy. With 35 years of experience managing the most diverse registry of potential unrelated blood stem cell donors and cord blood units in the world, NMDP/Be The Match is a proven partner in providing cures to patients with life-threatening blood and marrow cancers and diseases. Through their global network, they connect centers and patients to their best cell therapy option—from blood stem cell transplant to a next-generation therapy—and collaborate with cell and gene therapy companies to support therapy development and delivery through Be The Match BioTherapies®. NMDP/Be The Match is a tireless advocate for the cell therapy community, working with hematologists/oncologists to remove barriers to consultation and treatment, and supporting patients through no-cost programs to eliminate non-medical obstacles to cell therapy. In addition, they are a global leader in research through the CIBMTR® (Center for International Blood and Marrow Transplant Research®)—a collaboration with Medical College of Wisconsin, investing in and managing research studies that improve patient outcomes and advance the future of care

View source version on businesswire.com: https://www.businesswire.com/news/home/20230831050319/en/

03

11-month-old infant undergoes bone marrow transplant at RGGGH

RGGGH dean E. Theranirajan and the team of doctors with the 11-month-old baby who underwent bone marrow transplant.

An 11-month-old infant weighing five kilograms became the youngest and smallest patient to undergo a bone marrow transplant at the Rajiv Gandhi Government General Hospital (RGGGH).

Doctors said the child was diagnosed with severe combined immune deficiency (SCID), which is a life-threatening primary immune deficiency disorder. A fully HLA-matched donor’s stem cells will provide a cure for this disease by providing a functional immune system.

However, the age of the child, past severe infections, and the huge cost incurred are the hurdles for the treatment. The child underwent a bone marrow transplant with coverage under the Chief Minister’s Comprehensive Health Insurance Scheme.

Prior to transplant, the child had disseminated tuberculosis that was treated by the paediatric pulmonology department of the Institute of Child Health (ICH) and Hospital for Children. The child also underwent port-a-cath insertion at ICH’s Paediatric Surgery department.

He received a full HLA-matched unrelated donor’s stem cells from the DATRI stem cell registry. The child was in the hospital for two months for the treatment and was discharged 35 days after the transplantation. He will be receiving immunosuppressants and monthly immunoglobulin replacements for the next year until the new immune system reaches maturity. Doctors said he was the smallest child to be transplanted in the government hospital.

The team included RGGGH doctors from haematology, blood banking, nephrology, and the Intensive Care Unit, and ICH doctors from paediatric haematology, paediatric surgery, and paediatric pulmonology.

Aruna Rajendran, a haemato-oncologist and bone marrow transplant physician at Madras Medical College/RGGGH, said so far, 83 people have undergone bone marrow transplants at the hospital. E. Theranirajan, dean of RGGGH, said since starting paediatric bone marrow transplants, the demand has been increasing. “We have to take care of the quality of treatment. The treatment outcomes have been good so far, with a success rate of nearly 93 to 94%,” he said.

He added that in the future, screening for SCID could be brought into neonatal screening, particularly for high-risk families such as those with a history of consanguineous marriages and early neonatal deaths.